刘晓晔,女,汉族,中共党员,从事耐药菌防控工作已经近十年时间,长期致力于宿主导向的抗菌药物研发工作,对宿主细胞,细菌和抗菌药物三者之间的相互作用方式有系统的研究工作。以第一作者或通讯作者发表SCI论文12篇;中科院1区,IF>15分的top期刊文章有3篇,相关研究成果在Trends in Microbiology,Advanced Science, Biomaterials, Frontiers in pharmacology上以封面形式报道;在畜牧兽医杂志,中国兽医杂志,中国动物传染病学报等杂志上发表中文核心10篇;授权国家发明专利4项。主持国家自然科学青年基金、中国科协青年智库项目和北京市青年基金等科研项目6项。获得北京市科协青年人才托举工程1项。讲授《兽医药理学》、《药剂学》、《兽药创制与应用》、等课程,获得本科生和研究生优秀课程建设教改项目2项;参与中药助力乡村振兴等社会服务活动。担任Traditional Medicine Research和Zoonoses青年编委。联系方式:xiaoyeliu@bua.edu.cn或xiaoyeliu@pku.edu.cn
工作经历
2022.12 - 至今,bat365官方平台网站,副教授
2021.07 - 2022.11,bat365官方平台网站,讲师
2018.09 – 2021.07,北京大学,生物医学工程,博士后
科研经历
2014.09 - 2018.06,中国农业大学,兽医药理与毒理学,博士
2011.09 - 2014.06,bat365官方平台网站,中兽医,硕士
2007.09 - 2011.06,西南大学,动物医学,本科
发表SCI文章
1. Yu. F. #, Yu. X. #, Liu. R. #, Guo. D., Qian. D., Liang. B., Liu. X.*, Dong. H.* Dregs of Cardamine hupingshanensis as a feed additive improve egg quality. Front. Nutr. 2022, 9, 915865. IF=6.590, Q1
2. Song. L.#, Xin. H. #, Ren. X., Liu. J., Liu. X.*, Antibacterial modes of flavonoids combat resistant bacteria. Front. Pharmacol. 2022, 13, 873374. IF = 5.988 Q1
3. Liu. X.#, Wu. Y.#, Mao. C., Shen. J., Zhu. K.*, Host-acting antibacterial compounds combat cytosolic bacteria. Trends Microbiol. 2022, S0966-842X(22)00006-3. IF = 18.230, Q1
4. He. S.#, Deng. Q.#, Liang. B., Yu. F., Yu. X., Guo. D., Liu. X.*, Dong. H.*, Suppressing alpha-hemolysin as potential target to screen of flavonoids to combat bacterial coinfection. Molecules, 2021, 26, 7577. IF = 4.927, Q2
5. Liu,X., Zhu, K., Wang, P., Duan, X., Peng, W., Zhang, Y., Huang, J*, Extracellular matrix stiffness modulates host-bacteria interactions and antibiotic therapy of bacterial internalization. Biomaterials. 2021, 277, 121098. IF = 15.304, Q1
6. Liu, X. #, Zhang, Y.#, Li, Z., Zhang, P., Sun, Y*, Wu, Y. *. Paeoniflorin Derivative in Paeoniae Radix aqueous extract suppresses alpha-toxin of Staphylococcus aureus. Front. Microbiol. 2021, 12, 649390. IF=6.064, Q1
7. Liu, X.#, Liu, F.#, Ding, S., Shen, J.*, Zhu, K.*, Sublethal levels of antibiotics promote bacterial persistence in epithelial cells. Adv. Sci. 2020, 7, 1900840. IF = 17.521, Q1 封面文章
8. Liu, X.*, Zhang, H., He, S., Mu, X., Hu, G*, Dong, H*. Endothelial-derived interleukin-1alpha activates innate immunity by promoting the bactericidal activity of transendothelial neutrophils. Front. Cell. Dev. Biol. 2020, 8, 590. IF = 6.081, Q1
9. Liu, X.*, He, S., Li Q., Mu, X., Hu, G, Dong, H*. Comparison of the gut microbiota between Pulsatilla decoction and levofloxacin hydrochloride therapy on Escherichia coli infection. Front. Cell. Infect. 2020, 10, 319. IF = 6.073, Q2
10. Liu, X. #, Hu, Q.#, Xu, F., Ding, S., Zhu, K.*, Characterization of Bacillus cereus in the dairy products in China. Toxins. 2020, 12, 454 IF = 5.075, Q2
11. Liu, X., Ding, S., Shi, P., Dietrich, R., Martlbauer, E., and Zhu, K., Non-hemolytic enterotoxin of Bacillus cereus induces apoptosis in Vero cells. Cell Microbiol. 2017, 19, doi:10.1111/cmi.12684. IF = 4.816, Q2
12. Liu, X., Dong, H.*, Wang, M., Gao, Y., Zhang, T., Hu, G., Duan, H., and Mu, X.*, IL-1alpha-induced microvascular endothelial cells promote neutrophil killing by increasing MMP-9 concentration and lysozyme activity. Immunol Res, 2016, 64(1): 133-142.2. IF = 4.493, Q3
专利:
1. 黄建永,刘晓晔,抗细胞内细菌感染的抗菌药物药效评估方法及其应用(ZL202110106910.8)
2. 黄建永,刘晓晔,张海辉,一种各项异性刚度梯度水凝胶的制备方法及应用(ZL202011291184.3)
3. 丁双阳,朱奎,沈建忠,刘源,刘晓晔,崔一芳,夏曦,抗菌脂肽bacaucin衍生物及其在抑制细菌感染中的应用(ZL201611215268.2)
4. 丁双阳,朱奎,沈建忠,刘源,刘晓晔,崔一芳,夏曦,抗菌脂肽bacaucin及其制备方法与应用(ZL201611215276.7)