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侯晓林

[发表时间]：2023-01-01 [浏览次数]：

侯晓林 （1973.1- ）教授，基础兽医学学科带头人。 中国疾病预防与控制中心，公共卫生与预防医学博士后,中国农业大学基础兽医学博士

研究方向

兽医药物残留检测与细菌耐药性，动物疫病药物防控

科研项目

2016.1-2020.12 科技部十三五国家重点研发计划专项“畜禽重要病原耐药性检测与控制技术研究”课题“病原菌耐药性消减技术研究”（2016YFD0501307）

2013.1-2017.12 主持国家自然基金（31372485）连翘酯苷对鸡传染性支气管炎Toll受体7信号通路调控

2008.1-2010.12 主持国家863养殖与屠宰环境中药物污染检测技术专题（2007AA06Z404）

2007.9-2009.4  主持博士后一等自然科学基金“食品中违禁色素检测方法的研究(20070410096)”

主要发明专利

  1. 侯晓林 等 一种用于检测MCR-1的引物及其应用 申请号：201810558936.4

  2. 侯晓林;杨晓练 等 一种利巴韦林检测试纸条 - 201711078153.8

3. 侯晓林 等一种防治鸡大肠杆菌的药物及其制备方法 申请号：201410528264.4

  1. 侯晓林 等 肉与肉制品中猪源成分的检测方法、牛源成分的检测方法及羊源成分的检测方法-201410532343.2

  2. 侯晓林 等 肉与肉制品中马源成分的检测方法、驴源成分的检测方法 201410528241.3

  3. 刘凤华;许剑琴;侯晓林;高建明;史雅然;尹朋;牛卫宁一种治疗家畜子宫内膜炎的中药宫净灌注剂及其制备方法 - 201410802278.0

  4. 侯晓林等 检测环丙沙星的scFv抗体、其编码基因及应用 - 201110086885.8

  5. 郑志明 侯晓林 等 检测诺氟沙星的scFv抗体、其编码基因及应用 -201110074363.6


    主要论文与专著

  6. Tong Zhang, Deyin Li, Zhihua Jia, Jianyu Chang,and Xiaolin Hou* Cellular immune response in chickens infected with avian infectious bronchitis virus (IBV). European Journal of Inflammation 2017, 15(1) 35–41

  7. Ming Yang, Yan Lu, Yuanyuan Ma, Guoying Wu, Ross C. Beier, Xiaolin Hou* and Guojuan Wu  (2015) Inhibition of porcine reproductive and respiratory syndrome virus in vitro by Forsythoside A. Inter. J. Pharmacol. 11（4）, 394-399

  8. Zhang Y, Zhao H, Liu T, Wan C, Liu X, Gao Z, Hou X, Jiang L, Liu F (2015) Activation of transcription factor AP-1 in response to thermal injury in rat small intestine and IEC-6 cells. Bmc Gastroenterol 15: 83. doi:10.1186/s12876-015-0309-z

  9. Xu X, Li H, Hou X, Li D, He S, Wan C, Yin P, Liu M, Liu F, Xu J (2015) Punicalagin Induces Nrf2/HO-1 Expression via Upregulation of PI3K/AKT Pathway and Inhibits LPS-Induced Oxidative Stress in RAW264.7 Macrophages. Mediators Inflamm 2015: 380218. doi:10.1155/2015/380218

  10. Lu Y, Zhao H, Liu Y, Zhou X, Wang J, Liu T, Beier RC, Hou X (2015) Characterization of quinolone resistance in Salmonella enterica serovar Indiana from chickens in China. Poult Sci 94: 454-460. doi:10.3382/ps/peu133

  11. He S, Hou X, Xu X, Wan C, Yin P, Liu X, Chen Y, Shu B, Liu F, Xu J (2015) Quantitative proteomic analysis reveals heat stress-induced injury in rat small intestine via activation of the MAPK and NF-kappaB signaling pathways. Mol Biosyst 11: 826-834. doi:10.1039/c4mb00495g

  12. Zhong X, Shi Y, Chen J, Xu J, Wang L, Beier RC, Hou X, Liu F (2014) Polyphenol extracts from Punica granatum and Terminalia chebula are anti-inflammatory and increase the survival rate of chickens challenged with Escherichia coli. Biol Pharm Bull 37: 1575-1582.

  13. Lu Y, Zhao H, Sun J, Liu Y, Zhou X, Beier RC, Wu G, Hou X (2014) Characterization of multidrug-resistant Salmonella enterica serovars Indiana and Enteritidis from chickens in Eastern China. Plos One 9: e96050. doi:10.1371/journal.pone.0096050

  14. Liu X, Shi Y, Hou X, Wan C, He S, Chong X, Liu M, Li H, Liu F (2014) Microarray analysis of intestinal immune-related gene expression in heat-stressed rats. Int J Hyperthermia 30: 324-327. doi:10.3109/02656736.2014.939722

  15. Hou XL, Wu YL, Chen RX, Zhu Y, Lv Y, Xu XQ (2014) Evaluation of two modified quick, easy, cheap, effective, rugged and safe (QuEChERS) sample preparation methods for the analysis of baclofen and gabapentin in feeds by liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal 88: 53-59. doi:10.1016/j.jpba.2013.08.026

  16. Hou XL, Chen G, Zhu L, Yang T, Zhao J, Wang L, Wu YL (2014) Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk. J Chromatogr B Analyt Technol Biomed Life Sci 962: 20-29. doi:10.1016/j.jchromb.2014.05.005

  17. Wan C, Chen Y, Yin P, Han D, Xu X, He S, Liu M, Hou X, Liu F, Xu J (2014) Transport stress induces apoptosis in rat myocardial tissue via activation of the mitogen-activated protein kinase signaling pathways. Heart Vessels。doi:10.1007/s00380-014-0607-3

  18. Hou Xiaolin，Zhou Xuping，Li Qiuming，Lu Yan，Sun Yingjian，Wu Guojuan(2014)Preparation of Forsythiaside-hydroxypropyl-β-cyclodextrin Inclusion Complex and Its Characters.Animal Husbandry and Feed Science，2014，6 ( 2) : 46 －48，65

  19. Hou X, Zhou D, Huai W, Beier RC, Sun Y, Lu Y, Wu G, Sun Z, Wu Y (2013) Simultaneous determination of cyromazine and dicyclanil in animal edible tissues using UPLC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 30: 660-665. doi:10.1080/19440049.2012.760207

  20. Hou XL, Wu YL, Yang T, Du XD (2013) Multi-walled carbon nanotubes-dispersive solid-phase extraction combined with liquid chromatography-tandem mass spectrometry for the analysis of 18 sulfonamides in pork. J Chromatogr B. 929: 107-115. doi:10.1016/j.jchromb.2013.04.014

  21. Hou XL, Wu YL, Lv Y, Xu XQ, Zhao J, Yang T (2013) Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for determination of 10 cephalosporins and desacetylcefapirin in milk. J Chromatogr B 931: 6-11. doi:10.1016/j.jchromb.2013.05.006

  22. Xiaolin Hou , Shoujun Cao , Yan Lu , Yinliang Wu , Ross C. Beier & Yingjian Sun. An Enzyme-Linked Immunosorbent Assay for Determination of Dicyclanil in Animal Tissue. 2013 Analytical Letters, 46: 2870–2878

  23. Yu J, Liu F, Yin P, Zhao H, Luan W, Hou X, Zhong Y, Jia D, Zan J, Ma W, Shu B, Xu J (2013) Involvement of oxidative stress and mitogen-activated protein kinase signaling pathways in heat stress-induced injury in the rat small intestine. Stress 16: 99-113. doi:10.3109/10253890.2012.680526

  24. Liu X, Li H, Lu A, Zhong Y, Hou X, Wang N, Jia D, Zan J, Zhao H, Xu J, Liu F (2012) Reduction of intestinal mucosal immune function in heat-stressed rats and bacterial translocation. Int J Hyperthermia 28: 756-765. doi:10.3109/02656736.2012.729173

  25. Lu A, Wang H, Hou X, Li H, Cheng G, Wang N, Zhu X, Yu J, Luan W, Liu F, Xu J (2011) Microarray analysis of gene expression profiles of rat small intestine in response to heat stress. J Biomol Screen 16: 655-667. doi:10.1177/1087057111403928

  26. Hou X, Li Y, Wu G, Wang L, Hong M, Wu Y (2010) Determination of para red, Sudan dyes, canthaxanthin, and astaxanthin in animal feeds using UPLC. J Chromatogr Sci 48: 22-25.

  27. Xiaolin Hou, Yonggang Li, Shoujun Cao, Zhongwen Zhang,&, Yongnin Wu4 Analysis of Para Red and Sudan Dyes in Egg Yolk by UPLC–MS–MS. Chromatographia 2010, 71, 135–138

  28. Shi W, He J, Jiang H, Hou X, Yang J, Shen J (2006) Determination of multiresidue of avermectins in bovine liver by an indirect competitive ELISA. J Agric Food Chem 54: 6143-6146. doi:10.1021/jf060878v

  29. Xiaolin Hou, Yongnin Wu, Jianzhong Shen. Simultaneous analysis of avermectins in animal liver tissues by HPLC-fluroscence detector. Chromatographia 2007, 65 (January), 77-80.

  30. Xiaolin Hou, Xiaowei Li, Haiyang Jiang, Jianzhong Shen. Multi-residue analysis of avermectins in cattle liver by liquid chromagraphy tandem mass spectrometry. Journal of AOAC International. 2006. 89: 8, 1110-1115.

  31. Xiaolin Hou, Jihong He, Xiaowei Li, Shuangyang Ding, Jianzhong Shen. Simultaneous analysis of avermectins in bovine tissues by LC-MS/MS with immunoaffinity cleanup. Chromatographia. 2006, 63, 543-550.

  32. Hou Xiaolin, Shen Jianzhong, Zhang Suxia, Jiang Haiyang, Coats J R. Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii). Journal of Agricultural and Food Chemistry. 2003. 51, 7725-7729.

  33. He J, Hou X, Jiang H, Shen J (2005) Multiresidue analysis of avermectins in bovine liver by immunoaffinity column cleanup procedure and liquid chromatography with fluorescence detector. J Aoac Int 88: 1099-1103.

  34. Haiyang Jiang, Shuangyang Ding, Fei Xu, Sijun Zhao, Jihong He, Xiaolin Hou, Jianzhong Shen. Determination of eprinomectin in bovine urine and feces using HPLC with fluorescence detection. Chromatographia. 2007. 66, 411-414.

  35. Wu Xueli, Hou Xiaolin. Zhang Gong, Wu Yongnin, Simultaneous determination of malachite green, gentian violet, and their metabolites in aquatic products by high performance liquid chromatography-linear ion trap mass spectrometry. Journal of chromatography A. 2007.1172, 121-126.

  36. Jiang Haiyang, Hou Xiaolin, Shen Jianzhong. Residue depletion of eprinomectin in bovine tissues after subcutaneous administration. Journal of Agricultural and Food Chemistry. 2005. 53 (23): 9288-9292

  37. He Jihong, Hou Xiaolin, Shen Jianzhong, Jiang Haiyang. Multi-residue analysis of avermectins in bovine liver by immunoaffinity colum - liquid chromatography with fluorescence detector. J. of AOAC International. 2005. 88:4, 1099-1103.

  38. Hua Kuang, Hong Miao, Xiaolin Hou, Yun Feng Zhao, Jian Zhong Shen, Chuan Lai Xu，Yong Ning Wu. Determination of Pyrethroid Residues in Pork Muscle by Immunoaffinity Cleanup and GC-ECD. Chromatographia. 2009. DOI: 10.1365/s10337-009-1272-z.

  39. Hua Kuang; YongNing Wu, XiaoLin Hou; Hong Miao; Gong Zhang. Synthesis of derivatives and production of antiserum for class specific detection of pyrethroids by indirect ELISA Intern. J. Environ. Anal. Chem. 2009. 88(6), 423–437.

  40. He Jihong, Shen Jianzhong, Suo Xun, Hou Xiaolin. Development of A Monoclonal Antibody-Based ELISA for Detection of Sulfamethazine and N4-acetyl sulfamethazine in Chicken Breast Muscle Tissue. Journal of Food Science. 2005. 70 (1), 113-117